Harlequins captain Chris Robshaw is ready for the challenge presented by the Heineken Cup.
Scarlets battled their way to a 22-9 victory at Edinburgh, scoring tries through Nick Reynolds and Jordan Williams.
Sam Warburton will make his first appearance of the season for Cardiff against Leinster after recovering from injury.
Dragons continued their fine start to the Pro12 campaign by securing a 23-16 win in a Welsh derby against the Scarlets.
Leigh Halfpenny will make his first appearance for Cardiff this season while Munster look to make history in Italy.
Scrum-half Gareth Davies scored both Scarlets tries as the Welsh region recorded a 26-10 success over Treviso.
Week two of the Pro12 is rounded off on Saturday as Leinster host Ospreys before Treviso travel to face Scarlets.
Scarlets winger Kristian Phillips has been ruled out for up to six weeks after breaking his hand.
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